Department of Protein Engineering and Bioinformatics
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Head
Professor Alexander I.Kornelyuk,
Dr.Sci.(Biol.), Corresponding Member of NASU
Phone: (38 - 044) 526-55-89;
Fax: (38 - 044) 526-07-59;
E-mail: kornelyuk@imbg.org.ua
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Scientific direction:
Protein engineering
Structural bioinformatics
The ongoing research projects of the Department are focused on:
- Studies on molecular mechanisms of aminoacyl-tRNA synthetases (ARS) of
higher eukaryotes and the functional role of protein dynamics in the process of
protein-nucleic acid recognition.
- The methods of protein engineering are being used, aimed at the design of
new proteins with modified and unique properties.
- Gene engineering technologies for the cloning and expression of eukaryotic
proteins and their mutants have been developed.
- The structural and dynamic model of RNA recognition by ARSes is being
elaborated in the Department
- The experimental investigations on the intramolecular dynamics of proteins
are being performed using the methods of fluorescent spectroscopy. Also,
specific conformational alterations of enzymes, occurring in the process of
substrate recognition, are being studied.
Selected publications:
- Одинець К. О., Івахно С. С., Ковальський Д. Б., Токовенко Б. Т., Корнелюк О. І. Структурна біоінформатика в постгеномну еру // Біополімери і клітина.–2004.–Т. 20, № 1-2.–С. 78-91.
- Kovalskyy D., Dubyna V., Kanibolotsky D, Mark A. E., Kornelyuk A. // A molecular dynamics study of the structural stability of HIV-1 protease under physiological conditions: The role of Na+ ions in stabilizing the active site // Proteins.–2004.–v.57, N4, 780-788.
- Корнелюк А.И. Белковая инженерия , Биополимеры и клетка.- 2001, Т.17, №6, 520-532.
