Department of Synthetic Bioregulators

The main area of research is:

Design and development of biologically active compounds that offer great promise in the strategy of combating severe and fatal diseases.

Our ongoing scientific projects:

• Development of novel chemo therapeutic preparations, using modern methods of computer simulation and non-empirical quantum chemical calculations.
• Further design of these compounds aimed at obtaining effective substances possessing a wide spectrum of activity.
• Molecular testing and the selection of AIDS resistant cord blood samples for subsequent clinical use in AIDS patients.

Selected publications:

1. Palchikivska L.G., Platonov M.O., Alekseeva I. V., Shved A.D. Composite bioregulators based on the derivatives of phenazine -1 -carboxylic acid and triazine. Synthesis and structural characteristics. Biopolymers and cell 2003 - 19, № 3, 281-286.
2. Palchikivska L.G., Platonov M.O., Alekseeva I. V., Shved A.D. Design of potential inhibitors of transcription based on the derivatives of 6 aza- cytosine and 6 aza-iso-cytosine. Non-empiric quantum and chemical analysis, synthesis and physical-chemical investigation. Biopolymers and cell 2004 - 20, № 1-2, 131-142.
3. De Logu A., Palchykovska L. I., Kostina V. G., Shestakova T.S., Saddi M., Borgna R., Saddi B., Sanna C., Alexeeva I.V., Shved A.D. Phenazine-1-carboxylic acid derivatives suppressing the RNA polymerase as potential agents for the treatment of infections sustained by drug-resistant and MDR Mycobacterium tuberculosis// 25th Annual Congress of the European Society of Mycobacteriology, Algero-Sardinia, Italy, June, 27-30, 2004, Abstract Book, pp. 125.